The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.

  title={The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.},
  author={Zhihong Zhang and Yinsheng Wang and Li Yun Wu and Eric Fauman and Jeanne A. Stuckey and Heidi L. Schubert and Mark A Saper and Jack E. Dixon},
  volume={33 51},
The Yersinia protein tyrosine phosphatase (PTPase) was identified in the genus of bacteria responsible for the plague or the Black Death and was shown to be essential for pathogenesis. The three-dimensional structure of the catalytic domain of the Yersinia PTPase has been solved, and this information along with a detailed kinetic analysis has led to a better understanding of the catalytic mechanism of the PTPase. Mutational and chemical modification experiments have established that an… CONTINUE READING


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