The Current State of Naïve Human Pluripotency

  title={The Current State of Na{\"i}ve Human Pluripotency},
  author={Benjamin Thomas Dodsworth and Rowan Flynn and Sally A Cowley},
  booktitle={Stem cells},
Naïve or ground state pluripotency is a cellular state in vitro which resembles cells of the preimplantation epiblast in vivo. This state was first observed in mouse embryonic stem cells and is characterized by high rates of proliferation, the ability to differentiate widely, and global hypomethylation. Human pluripotent stem cells (hPSCs) correspond to a later or "primed" stage of embryonic development. The conversion of hPSCs to a naïve state is desirable as their features should facilitate… CONTINUE READING