The Current Obesity Epidemic: Unravelling the Evolutionary Legacy ofAdipose Tissue

@article{Zafon2011TheCO,
  title={The Current Obesity Epidemic: Unravelling the Evolutionary Legacy ofAdipose Tissue},
  author={Carles Zafon and Rafael Sim{\'o}},
  journal={The Open Obesity Journal},
  year={2011},
  volume={3},
  pages={98-106}
}
The evolution of organisms is shaped by the selective pressures to which they are subject. Selective pressures produce a trade-off between costs and benefits that ultimately influences the fitness of the whole organism. Classically, it has been pointed out that food intake is allocated between its use for physiological functions and its store for future utilization. Moreover, it is accepted that the perfect survivor must be able to eat and store as many calories as possible when food is… 
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References

SHOWING 1-10 OF 137 REFERENCES
Fat and aging: a tale of two tissues.
  • C. Zafon
  • Biology
    Current aging science
  • 2009
TLDR
In summary, adipose tissue modifications promote REE strategies, and fat redistribution could be thought of as a consequence of the TAH.
Human obesity: an evolutionary approach to understanding our bulging waistline
  • A. Lev‐Ran
  • Medicine
    Diabetes/metabolism research and reviews
  • 2001
TLDR
The unique worldwide spread of the human species and the remarkably long post‐reproductive survival show that the authors' genome permits excellent adaptation to vastly different environments, and public health measures should be aggressively directed at the prevention of obesity from childhood.
The evolution of human fatness and susceptibility to obesity: an ethological approach
  • J. Wells
  • Biology
    Biological reviews of the Cambridge Philosophical Society
  • 2006
TLDR
The proximate causes, ontogeny, fitness value and evolutionary history of human fat deposition are considered, and Alterations to the obesogenic environment are predicted to play a key role in reducing the prevalence of obesity.
Evolutionary origins of obesity
  • A. Bellisari
  • Biology
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2008
TLDR
In the modern obesogenic environment, individuals possessing the appropriate combination of ancestral energy‐conserving genes are at greater risk for overweight and obesity and associated chronic diseases.
Oscillations in total body fat content through life: an evolutionary perspective
  • C. Zafon
  • Biology
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2007
TLDR
The aim of this review is to focus on the age‐related changes in fat depots and an evolutionary explanation to the observed changes has been emphasized.
Epidemic Inflammation: Pondering Obesity
  • C. Nathan
  • Medicine, Biology
    Molecular medicine
  • 2008
TLDR
Evidence that reactive oxygen and nitrogen intermediates (ROI and RNI) help drive chronic inflammation in the obese is reviewed and this is proposed to be a maladaptive instance of the authors' evolved dependence on ROI andRNI for both homeostatic signaling and host defense.
Feeding behavior, obesity, and neuroeconomics
Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the ‘drifty gene’ hypothesis
TLDR
It is shown that the reduced fecundity argument is flawed because famines are almost universally followed by periods of enhanced fecundness, which offsets the decline observed during the famine itself, and the net effect of famines on fecundities is consequently insufficient to rescue the thrifty gene idea.
Feeding Our Immune System: Impact on Metabolism
TLDR
It is shown how the highly energy-demanding immune cells use glucose as a main source of fuel in a way similar to that of insulin-responsive adipose tissue and how Toll-like receptors of the innate immune system are presently viewed as essential actors in the complex balance ensuring bodily immune and metabolic health.
Adipose tissue in human infancy and childhood: an evolutionary perspective.
  • C. Kuzawa
  • Medicine
    American journal of physical anthropology
  • 1998
TLDR
Well-fed infants acquire peak fat reserves by an age of peak prevalence of malnutrition, infectious disease, and fat reserve depletion in less-buffered contexts, and childhood--characterized by minimal investment in the tissue--is a stage of reduced risk of energy stress.
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