The Current Epidemiologic Evidence on Exposures to Poly- and Perfluoroalkyl Substances (PFASs) and Male Reproductive Health

  title={The Current Epidemiologic Evidence on Exposures to Poly- and Perfluoroalkyl Substances (PFASs) and Male Reproductive Health},
  author={Melissa J. Perry and GiaLinh N. Nguyen and Nicholas K. Porter},
  journal={Current Epidemiology Reports},
Environmental epidemiologists have given heightened research attention to the class of poly- and perfluoroalkyl substances, or PFASs, in recent years due to their ubiquity, persistence, and evidence of hormonal activity. Whereas prevalence studies have documented changes in serum levels over time among populations in the USA and elsewhere, few human reproductive health studies have been conducted. Given the weight of evidence demonstrating that hormonally active synthetic compounds can impact… 

Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence

Assessment of available evidence on associations between PFAS exposures in different stages of life and semen quality, reproductive hormones, cryptorchidism, hypospadias, and testicular cancer concluded that a lack of consistency across studies limited conclusions of overall evidence.

Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS

Combined maternal PFAS exposure was associated with lower sperm concentration, total sperm count, and a higher proportion of nonprogressive and immotile sperm in the young men in the FEPOS cohort, indicating consistent inverse associations between exposure to maternalPFAS and semen quality.

Fabrication of Few-Layered Porous Graphite for Removing Fluorosurfactant from Aqueous Solution.

  • T. WuZhimin Wu Xiang Cai
  • Chemistry, Engineering
    Langmuir : the ACS journal of surfaces and colloids
  • 2018
It is indicated that FPG could serve as a promising adsorbent for the removal of fluorosurfactant in waste water and was attributed to its unique physical properties, such as high porosity, high hydrophobicity, low density, and excellent heat stability.



Associations of in Utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men

In utero exposure to PFOA may affect adult human male semen quality and reproductive hormone levels, and Multivariable linear regression analysis suggested that in utero exposed men may have lower adjusted sperm concentration and total sperm count and with higher adjusted levels of luteinizing hormone.

Endocrine disrupting properties of perfluorooctanoic acid

Exposure to Perfluoroalkyl Substances and Sperm DNA Global Methylation in Arctic and European Populations

Investigation of the associations between exposure to PFASs and sperm global methylation levels in a population of non‐occupationally exposed fertile men found no major consistent associations, but weak but statistically significant associations of differentPFASs with DNA hypo‐ and hyper‐methylation were found in some of the studied populations.

Do Perfluoroalkyl Compounds Impair Human Semen Quality?

High PFAA levels were associated with fewer normal sperm, which may contribute to the otherwise unexplained low semen quality often seen in young men, and these findings need to be corroborated in larger studies.

Exposure to perfluorinated compounds and human semen quality in Arctic and European populations.

The most robust finding in the present study was the negative associations between PFOS exposure and sperm morphology suggesting adverse effects of PFOS on semen quality, possibly due to interference with the endocrine activity or sperm membrane function.

Alternatives to PFASs: Perspectives on the Science

The FluoroCouncil supports the call to action from the scientific and professional community to limit the production and environmental release of long-chain PFASs but states that “the short- Chain PFAS substances studied to date are not expected to harm human health or the environment,” as they “are eliminated more rapidly from the body and are less toxic than long- chain substances”.

Direct action of endocrine disrupting chemicals on human sperm

It is concluded that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

Association between Perfluorinated Compound Exposure and Miscarriage in Danish Pregnant Women

A case-control study within a population-based, prospective cohort of newly pregnant women residing in the Municipality of Odense, Denmark, finding that women with the highest tertile of exposure to perfluorononanoic acid and perfluorohexane sulfonic acid in pregnancy had odds ratios for miscarriage, requires confirmation due to the possible public health importance.