The Cullin Rtt101p Promotes Replication Fork Progression through Damaged DNA and Natural Pause Sites

@article{Luke2006TheCR,
  title={The Cullin Rtt101p Promotes Replication Fork Progression through Damaged DNA and Natural Pause Sites},
  author={Brian Luke and Gwennaelle Versini and Malika Jaquenoud and Iram Waris Zaidi and Thimo Kurz and Lionel Pintard and Philippe Pasero and Matthias Peter},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={786-792}
}
Accurate and complete DNA replication is fundamental to maintain genome integrity. While the mechanisms and underlying machinery required to duplicate bulk genomic DNA are beginning to emerge, little is known about how cells replicate through damaged areas and special chromosomal regions such as telomeres, centromeres, and highly transcribed loci . Here, we have investigated the role of the yeast cullin Rtt101p in this process. We show that rtt101Delta cells accumulate spontaneous DNA damage… CONTINUE READING