The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.

@article{Lee2010TheC3,
  title={The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.},
  author={Yu-ru Lee and Wei-Chien Yuan and Hsuan-Chung Ho and Congcong Chen and Hsiu-ming Shih and Ruoshi Chen},
  journal={The EMBO journal},
  year={2010},
  volume={29 10},
  pages={
          1748-61
        }
}
Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAPK activation remains largely unknown. Here, we identify the BTB-Kelch protein KLHL20 as a negative regulator of DAPK. KLHL20 binds DAPK and Cullin 3 (Cul3) via its Kelch-repeat domain and BTB domain, respectively. The KLHL20-Cul3-ROC1 E3 ligase complex promotes DAPK polyubiquitination, thereby inducing the proteasomal degradation of DAPK. Accordingly, depletion of… CONTINUE READING
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