The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+.

@article{Gryllos2003TheCT,
  title={The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+.},
  author={Ioannis Gryllos and James C Levin and Michael R. Wessels},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 7},
  pages={4227-32}
}
Group A streptococci control expression of key virulence determinants via the two-component sensorregulator system CsrRCsrS. The membrane-bound sensor CsrS is thought to respond to previously unknown environmental signal(s) by controlling phosphorylation of its cognate regulator component CsrR. Phosphorylation of CsrR increases its affinity for binding to the promoter regions of Csr-regulated genes to repress transcription. Here we show that environmental Mg(2+) concentration is a potent and… CONTINUE READING

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