The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation.

@article{Loedige2015TheCS,
  title={The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation.},
  author={Inga Loedige and Leonhard Jakob and Thomas Treiber and Debashish Ray and Mathias Michael Stotz and Nora Treiber and Janosch Hennig and Kate B. Cook and Quaid D Morris and Timothy R. Hughes and Julia C. Engelmann and Michael P Krahn and Gunter Meister},
  journal={Cell reports},
  year={2015},
  volume={13 6},
  pages={
          1206-1220
        }
}
TRIM-NHL proteins are conserved among metazoans and control cell fate decisions in various stem cell linages. The Drosophila TRIM-NHL protein Brain tumor (Brat) directs differentiation of neuronal stem cells by suppressing self-renewal factors. Brat is an RNA-binding protein and functions as a translational repressor. However, it is unknown which RNAs Brat regulates and how RNA-binding specificity is achieved. Using RNA immunoprecipitation and RNAcompete, we identify Brat-bound mRNAs in… CONTINUE READING
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