The Crystal Structure of Uncomplexed Actin in the ADP State

@article{Otterbein2001TheCS,
  title={The Crystal Structure of Uncomplexed Actin in the ADP State},
  author={L. Otterbein and P. Graceffa and R. Dominguez},
  journal={Science},
  year={2001},
  volume={293},
  pages={708 - 711}
}
The dynamics and polarity of actin filaments are controlled by a conformational change coupled to the hydrolysis of adenosine 5′-triphosphate (ATP) by a mechanism that remains to be elucidated. Actin modified to block polymerization was crystallized in the adenosine 5′-diphosphate (ADP) state, and the structure was solved to 1.54 angstrom resolution. Compared with previous ATP-actin structures from complexes with deoxyribonuclease I, profilin, and gelsolin, monomeric ADP-actin is characterized… Expand
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