The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator

@inproceedings{Ost2015TheCN,
  title={The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator},
  author={Kyla S. Ost and Teresa R. O’Meara and Naureen Huda and Shannon K Esher and J Andrew Alspaugh},
  booktitle={PLoS genetics},
  year={2015}
}
The Rim101/PacC transcription factor acts in a fungal-specific signaling pathway responsible for sensing extracellular pH signals. First characterized in ascomycete fungi such as Aspergillus nidulans and Saccharomyces cerevisiae, the Rim/Pal pathway maintains conserved features among very distantly related fungi, where it coordinates cellular adaptation to alkaline pH signals and micronutrient deprivation. However, it also directs species-specific functions in fungal pathogens such as… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS