The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).

@article{Sollerbrant2003TheCA,
  title={The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).},
  author={Kerstin Sollerbrant and Elisabeth Raschperger and Momina Mirza and Ulla Engstrom and L. Philipson and Per Olof Ljungdahl and Ralf F. Pettersson},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 9},
  pages={7439-44}
}
The Coxsackievirus and adenovirus receptor (CAR) functions as a virus receptor, but its primary biological function is unknown. A yeast two-hybrid screen was used to identify Ligand-of-Numb protein-X (LNX) as a binding partner to the intracellular tail of CAR. LNX harbors several protein-protein interacting domains, including four PDZ domains, and was previously shown to bind to and regulate the expression level of the cell-fate determinant Numb. CAR was able to bind LNX both in vivo and in… CONTINUE READING

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