The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates.

Abstract

The intracellular bacterial pathogen Coxiella burnetii directs biogenesis of a phagolysosome-like parasitophorous vacuole (PV), in which it replicates. The organism encodes a Dot/Icm type IV secretion system (T4SS) predicted to deliver to the host cytosol effector proteins that mediate PV formation and other cellular events. All C. burnetii isolates carry a… (More)
DOI: 10.1128/JB.01359-10

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