The Counteraction of Opioid-Induced Ventilatory Depression by the Serotonin 1A-Agonist 8-OH-DPAT Does Not Antagonize Antinociception in Rats In Situ and In Vivo

@article{Guenther2009TheCO,
  title={The Counteraction of Opioid-Induced Ventilatory Depression by the Serotonin 1A-Agonist 8-OH-DPAT Does Not Antagonize Antinociception in Rats In Situ and In Vivo},
  author={U. Guenther and T. Manzke and H. Wrigge and Matthias Dutschmann and J. Zinserling and C. Putensen and A. Hoeft},
  journal={Anesthesia \& Analgesia},
  year={2009},
  volume={108},
  pages={1169-1176}
}
BACKGROUND: Spontaneous breathing during mechanical ventilation is gaining increasing importance during intensive care but is depressed by narcotics, such as opioids. Serotonin 1A-receptor (5-HT1A-R) agonists have been shown to antagonize opioid-induced ventilatory depression, but both enhancement and attenuation of nociceptive reflexes have been found with different experimental models. To clarify contradictory findings, we simultaneously determined dose-response functions of the standard 5… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats.
Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.
5-HT4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia
The effect of 5-HT1A receptor stimulation on nociceptive dorsal horn neurones in rats.
...
1
2
3
4
5
...