The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways.

@article{Xiao2016TheCR,
  title={The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways.},
  author={Xiang Xiao and Xiaomin Shi and Yihui Fan and Chenglin Wu and Xiaolong Zhang and Laurie J Minze and Wen-tao Liu and Rafik Mark Ghobrial and Peixiang Lan and Xian Chang Li},
  journal={Immunity},
  year={2016},
  volume={44 6},
  pages={1271-83}
}
T helper 17 (Th17) cells are prominently featured in multiple autoimmune diseases, but the regulatory mechanisms that control Th17 cell responses are poorly defined. Here we found that stimulation of OX40 triggered a robust chromatin remodeling response and produced a "closed" chromatin structure at interleukin-17 (IL-17) locus to inhibit Th17 cell function. OX40 activated the NF-κB family member RelB, and RelB recruited the histone methyltransferases G9a and SETDB1 to the Il17 locus to deposit… CONTINUE READING
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