The Cost-Effectiveness of Clozapine

@article{Morris1998TheCO,
  title={The Cost-Effectiveness of Clozapine},
  author={Stephen Morris and Thomas Hogan and Alistair Mcguire},
  journal={Clinical Drug Investigation},
  year={1998},
  volume={15},
  pages={137-152}
}
SummaryTreatment-resistant schizophrenia is a severely debilitating and costly disease. While clozapine is reported to be an effective therapy for treatment-resistant schizophrenia, it is nevertheless largely underutilised. A review of published cost-effectiveness studies of clozapine conducted in the USA, UK, Sweden and Canada, and employing a variety of study designs, reveals consistent reporting of clinical efficacy, cost and cost-effectiveness findings in favour of clozapine over… 
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Background Citations
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12 Citations

Pharmacoeconomics of Clozapine, Risperidone and Olanzapine

While all 3 antipsychotics improved clinical outcomes, the literature suggests that clozapine is cost effective in patients with treatment-refractory symptoms, whereas risperidone and olanzapine may be cost neutral.

Cost of the Illness of Treatment-Resistant Schizophrenia

Treatment with clozapine is not associated with a significant increase in the overall treatment cost, in the short term, however, there is a significant reduction in direct treatment costs.

Where to Position Clozapine: Re-Examining the Evidence

Schizophrenia continues to represent a treatment challenge, with many people demonstrating suboptimal response and poor functional outcome, but in light of existing evidence this warrants re-examination of clozapine.

Outcomes for schizophrenia patients with clozapine treatment: how good does it get?

The recommendation of prolonged clozapine trials to improve cost-effectiveness in the most seriously unwell schizophrenia patients is supported, and continuing treatment was associated with real-world improvements in functional and clinical outcomes.

Clozapine: the first atypical antipsychotic

The rapid increase in the distribution of clozapine dramatically stopped in 1974, when 16 patients developed agranulocytosis under clozAPine treatment and eight of them died, while in the German speaking countries, due to the intervention of several renowned psychiatrists, it was not withdrawn and since then is prescribed under precautionary restrictions.

The newer antipsychotics: evidence for cost-effectiveness and policy implications

There are ethical, clinical and political grounds for increasing funding for the treatment of schizophrenia to take advantage of the biggest revolution in antipsychotic therapy since the launch of the first neuroleptics.

Cost analysis of treating schizophrenia with amisulpride: Naturalistic mirror image study

Costs of Inpatient Care for Schiaophrenia at Khon Kaen Rajanagarindra Psychiatric Hospital

Factors associated with the total direct cost for inpatient schizophrenia were gender, age, type of payment scheme and behavior under surveillance.

Ökonomie und Arzneimittelsicherheit

Bedingt durch wachsenden gesundheitspolitischen Finanzierungsdruck gewinnen pharmakookonomische Studien gerade im Bereich der kostenintensiven psychiatrischen Versorgung zunehmend an Bedeutung wirklich hohere Lebensqualitat fur die Betroffenen und eroffnen grosere Rehabilitationschancen.

Costes y resultados del tratamiento con risperidona en la esquizofrenia en la República Checa

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