The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study

@article{Kwako2015TheCR,
  title={The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study},
  author={Laura E Kwako and Primavera Alessandra Spagnolo and Melanie L. Schwandt and Annika Thorsell and David Ted George and Reza Momenan and Daniel E. Rio and Marilyn A Huestis and S{\'e}bastien Anizan and Marta Concheiro and Rajita Sinha and Markus Heilig},
  journal={Neuropsychopharmacology},
  year={2015},
  volume={40},
  pages={1053-1063}
}
Extensive preclinical data implicate corticotropin-releasing hormone (CRH), acting through its CRH1 receptor, in stress- and dependence-induced alcohol seeking. We evaluated pexacerfont, an orally available, brain penetrant CRH1 antagonist for its ability to suppress stress-induced alcohol craving and brain responses in treatment seeking alcohol-dependent patients in early abstinence. Fifty-four anxious alcohol-dependent participants were admitted to an inpatient unit at the NIH Clinical Center… CONTINUE READING
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