Hand preference is the most studied form of lateralization. Left-handers have coexisted with righthanders at least since the Upper Paleolithic and left-handers are in the minority in all human populations. Handedness is not neutral and some costs are associated with left handedness. The most frequency cited costs are a reduced longevity, a smaller height and weight, late puberty and a larger developmental instability. The persistence of the polymorphism of handedness is interesting and suggests that left-handedness must be associated with some benefits. In humans has been proposed that it is maintained by negative frequency-dependent selection. In this study, the relationship between psychological and motor systems was investigated and the correlation between handedness, eyedness, footedness and combination of them with intelligence were determined. Nonverbal intelligence was assed using the Persian transltion of WAIS-R. T-test was applied for comparison between groups; the results indicated that those use right hand and right eye and individual with left hand and right eye have much higher creativity in comparison with others.