The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes

@article{LunaPelez2019TheCD,
  title={The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes},
  author={Noelia Luna-Pel{\'a}ez and R. March-D{\'i}az and M. Ceballos-Ch{\'a}vez and Jos{\'e} A. Guerrero-Mart{\'i}nez and P. Grazioli and P. Garc{\'i}a-Guti{\'e}rrez and T. Vaccari and Valentina Massa and J. Reyes and M. Garc{\'i}a-Dom{\'i}nguez},
  journal={Cell Death & Disease},
  year={2019},
  volume={10}
}
  • Noelia Luna-Peláez, R. March-Díaz, +7 authors M. García-Domínguez
  • Published 2019
  • Biology, Medicine
  • Cell Death & Disease
  • Mutations in NIPBL are the major cause of Cornelia de Lange Syndrome (CdLS). NIPBL is the cohesin-loading factor and has recently been associated with the BET (bromodomains and extra-terminal (ET) domain) proteins BRD2 and BRD4. Related to this, a CdLS-like phenotype has been described associated to BRD4 mutations. Here, we show direct interaction of NIPBL with different BET members in yeast, and selective interaction with BRD4 in cells, being the ET domain involved in the interaction. To… CONTINUE READING
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    References

    SHOWING 1-10 OF 64 REFERENCES
    A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS
    • 91
    • PDF
    Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior
    • 31
    • PDF