The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote

@article{Hinchcliffe1998TheCO,
  title={The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote },
  author={Edward H. Hinchcliffe and Grizzel O. Cassels and Conly L. Rieder and Greenfield Sluder},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={1417 - 1426}
}
Centrosomes repeatedly reproduce in sea urchin zygotes arrested in S phase, whether cyclin-dependent kinase 1-cyclin B (Cdk1-B) activity remains at prefertilization levels or rises to mitotic values. In contrast, when zygotes are arrested in mitosis using cyclin B Delta-90, anaphase occurs at the normal time, yet centrosomes do not reproduce. Together, these results reveal the cell cycle stage specificity for centrosome reproduction and demonstrate that neither the level nor the cycling of Cdk1… CONTINUE READING