The Cool-2/α-Pix Protein Mediates a Cdc42-Rac Signaling Cascade

  title={The Cool-2/α-Pix Protein Mediates a Cdc42-Rac Signaling Cascade},
  author={Dan Baird and Qiyu Feng and Richard A. Cerione},
  journal={Current Biology},
an SH3 domain, followed by a tandem arrangement of Background: Cloned-out of library-2 (Cool-2)/PAK-interDbl homology (DH) and Pleckstrin homology (PH) doactive exchange factor ( -Pix) was identified through mains [6]. This arrangement of DH and PH domains is its ability to bind the Cdc42/Rac target p21-activated characteristic of the Dbl family of guanine nucleotide kinase (PAK) and has been implicated in certain forms exchange factors (GEFs) for Rho-related GTP binding of X-linked mental… CONTINUE READING
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Dual mechanisms for activation of the Dbl - family Guanine nucleotide exchange [ 3 H ] GDP Dissociation Assay factor p 90 Cool - 2 /  - Pix

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RhoG activates Rac 1 by directAccepted : November 1 , 2004 interaction with the Dock 180 - binding protein Elmo

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