The Contributions of Cyclooxygenase-2 to Tumor Angiogenesis

  title={The Contributions of Cyclooxygenase-2 to Tumor Angiogenesis},
  author={Stephen T Gately},
  journal={Cancer and Metastasis Reviews},
Cyclooxygenase-2 (COX-2) is an immediate early response gene that can be induced by a variety of tumor promoters, cytokines, growth factors and hypoxia. COX-2 overexpression is linked to all stages of carcinogenesis with the enzyme localized to the neoplastic cells, microvascular endothelial cells, and stromal fibroblasts. The contributions of COX-2 in tumor angiogenesis include: (a) the increased expression of the proangiogenic growth factor VEGF; (b) the production of the eicosanoid products… CONTINUE READING