The Contribution of the Blood Glutamate Scavenging Activity of Pyruvate to its Neuroprotective Properties in a Rat Model of Closed Head Injury

@article{Zlotnik2007TheCO,
  title={The Contribution of the Blood Glutamate Scavenging Activity of Pyruvate to its Neuroprotective Properties in a Rat Model of Closed Head Injury},
  author={Alexander Zlotnik and B. M. Gurevich and Evgenia Cherniavsky and Sergei Tkachov and Angela Matuzani-Ruban and Avner Leon and Yoram Shapira and Vivian Itzhak Teichberg},
  journal={Neurochemical Research},
  year={2007},
  volume={33},
  pages={1044-1050}
}
The removal of excess glutamate from brain fluids after acute insults such as closed head injury (CHI) and stroke is expected to prevent excitotoxicity and the ensuing long lasting neurological deficits. Since blood glutamate scavenging accelerates the removal of excess glutamate from brain into blood and causes neuroprotection, we have evaluated here whether the neuroprotective properties of pyruvate could be partly accounted to its blood glutamate scavenging activity. The neurological outcome… CONTINUE READING