The Contribution of Genetic Recombination to CRISPR Array Evolution

Abstract

CRISPR (clustered regularly interspaced short palindromic repeats) is a microbial immune system against foreign DNA. Recognition sequences (spacers) encoded within the CRISPR array mediate the immune reaction in a sequence-specific manner. The known mechanisms for the evolution of CRISPR arrays include spacer acquisition from foreign DNA elements at the… (More)
DOI: 10.1093/gbe/evv113

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