The Contribution of Angiogenesis to the Process of Metastasis.

  title={The Contribution of Angiogenesis to the Process of Metastasis.},
  author={Diane Renee Bielenberg and Bruce R. Zetter},
  journal={Cancer journal},
  volume={21 4},
The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites. We also discuss the role of tumor lymphangiogenesis as a means of dissemination of lymphatic… CONTINUE READING
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