The Consumption of Prothrombin during Coagulation: The Defect in Haemophilia and Thrombo-Cytopenic Purpura.

  • C Merskey
  • Published 1950 in Journal of clinical pathology


During the process of normal blood coagulation prothrombin is converted into thrombin. As a result serum contains considerably less prothrombin than the plasma from which it is derived, the prothrombin having been consumed during the coagulation of the blood. In certain conditions this conversion is incomplete and much prothrombin remains in the serum… (More)


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