The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila

@article{Karres2007TheCM,
  title={The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila},
  author={Janina S. Karres and Val{\'e}rie Hilgers and In{\'e}s Carrera and Jessica E Treisman and Stephen Michael Cohen},
  journal={Cell},
  year={2007},
  volume={131},
  pages={136-145}
}
microRNAs (miRNAs) bind to specific messenger RNA targets to posttranscriptionally modulate their expression. Understanding the regulatory relationships between miRNAs and targets remains a major challenge. Many miRNAs reduce expression of their targets to inconsequential levels. It has also been proposed that miRNAs might adjust target expression to an optimal level. Here we analyze the consequences of mutating the conserved miRNA miR-8 in Drosophila. We identify atrophin as a direct target of… CONTINUE READING
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