The Consensus Molecular Subtypes of Colorectal Cancer

@article{Guinney2015TheCM,
  title={The Consensus Molecular Subtypes of Colorectal Cancer},
  author={J. Guinney and R. Dienstmann and X. Wang and A. de Reyni{\`e}s and A. Schlicker and C. Soneson and L. Marisa and P. Roepman and G. Nyamundanda and P. Angelino and B. Bot and Jeffrey S. Morris and I. Simon and S. Gerster and E. Fessler and F. de Sousa e Melo and E. Missiaglia and H. Ramay and D. Barras and K. Homicsko and D. Maru and G. Manyam and B. Broom and V. Boige and B. Perez-Villamil and Ted Laderas and R. Salazar and J. Gray and D. Hanahan and J. Tabernero and R. Bernards and S. Friend and P. Laurent-Puig and J. Medema and A. Sadanandam and L. Wessels and M. Delorenzi and S. Kopetz and L. Vermeulen and S. Tejpar},
  journal={Nature medicine},
  year={2015},
  volume={21},
  pages={1350 - 1356}
}
Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. [...] Key Method To resolve inconsistencies among the reported gene expression–based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing…Expand

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This mini review will give some information about the most frequent molecular genetics changes in colorectal cancer and its molecular classification in four CMS subtypes due to its morphology, gene expression profile, somatic mutations and microsatellite instability. Expand
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