The Consensus 5' Splice Site Motif Inhibits mRNA Nuclear Export

@article{Lee2015TheC5,
  title={The Consensus 5' Splice Site Motif Inhibits mRNA Nuclear Export},
  author={Eliza S. Lee and Abdalla Akef and Kohila Mahadevan and Alexander F Palazzo},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
In eukaryotes, mRNAs are synthesized in the nucleus and then exported to the cytoplasm where they are translated into proteins. We have mapped an element, which when present in the 3’terminal exon or in an unspliced mRNA, inhibits mRNA nuclear export. This element has the same sequence as the consensus 5’splice site motif that is used to define the start of introns. Previously it was shown that when this motif is retained in the mRNA, it causes defects in 3’cleavage and polyadenylation and… Expand
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