The Consensus 5' Splice Site Motif Inhibits mRNA Nuclear Export

Abstract

In eukaryotes, mRNAs are synthesized in the nucleus and then exported to the cytoplasm where they are translated into proteins. We have mapped an element, which when present in the 3'terminal exon or in an unspliced mRNA, inhibits mRNA nuclear export. This element has the same sequence as the consensus 5'splice site motif that is used to define the start of… (More)
DOI: 10.1371/journal.pone.0122743

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