The Congenital Cataract-Linked G61C Mutation Destabilizes γD-Crystallin and Promotes Non-Native Aggregation

@inproceedings{Zhang2011TheCC,
  title={The Congenital Cataract-Linked G61C Mutation Destabilizes γD-Crystallin and Promotes Non-Native Aggregation},
  author={Wang Cheng Zhang and Hong-Chen Cai and Fei-feng Li and Yi-Bo Xi and Xu Ma and Yong-bin Yan},
  booktitle={PloS one},
  year={2011}
}
γD-crystallin is one of the major structural proteins in human eye lens. The solubility and stability of γD-crystallin play a crucial role in maintaining the optical properties of the lens during the life span of an individual. Previous study has shown that the inherited mutation G61C results in autosomal dominant congenital cataract. In this research, we studied the effects of the G61C mutation on γD-crystallin structure, stability and aggregation via biophysical methods. CD, intrinsic and… CONTINUE READING

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