The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

@article{Willemsen2015TheCA,
  title={The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium},
  author={Gonneke Willemsen and Kirsten Ward and Christopher G. Bell and Kaare Christensen and Jocelyn Bowden and Christine Dalg{\aa}rd and Jennifer R. Harris and Jaakko A Kaprio and Robert Lyle and Patrik K. E. Magnusson and Karen A. Mather and Juan Ram{\'o}n Ordo{\~n}ana and Francisco P{\'e}rez-Riquelme and Nancy L. Pedersen and Kirsi H Pietil{\"a}inen and Perminder Singh Sachdev and Dorret I. Boomsma and Tim D. Spector},
  journal={Twin Research and Human Genetics},
  year={2015},
  volume={18},
  pages={762 - 771}
}
Twin pairs discordant for disease may help elucidate the epigenetic mechanisms and causal environmental factors in disease development and progression. To obtain the numbers of pairs, especially monozygotic (MZ) twin pairs, necessary for in-depth studies while also allowing for replication, twin studies worldwide need to pool their resources. The Discordant Twin (DISCOTWIN) consortium was established for this goal. Here, we describe the DISCOTWIN Consortium and present an analysis of type 2… 
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