The Concept of Clinically Meaningful Difference in Health-Related Quality-of-Life Research

@article{Hays2000TheCO,
  title={The Concept of Clinically Meaningful Difference in Health-Related Quality-of-Life Research},
  author={Prof. Ron D. Hays and J. Michael Woolley},
  journal={PharmacoEconomics},
  year={2000},
  volume={18},
  pages={419-423}
}
It is generally believed that small differences in health-related quality of life (HR-QOL) may be statistically significant yet clinically unimportant. The concept of the minimal clinically meaningful difference (MCID) has been proposed to refer to the smallest difference in a HR-QOL score that is considered to be worthwhile or clinically important.However, there is danger in oversimplification in asking the question: what is the MCID on this HR-QOL instrument? We argue that the attempt to… CONTINUE READING

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