• Corpus ID: 244714523

The Computational Drug Repositioning without Negative Sampling

  title={The Computational Drug Repositioning without Negative Sampling},
  author={Xinxing Yang and Gen-ke Yang and Jian Chu},
Computational drug repositioning technology is an effective tool to accelerate drug development. Although this technique has been widely used and successful in recent decades, many existing models still suffer from multiple drawbacks such as the massive number of unvalidated drug-disease associations and the inner product. The limitations of these works are mainly due to the following two reasons: firstly, previous works used negative sampling techniques to treat unvalidated drug-disease… 


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