The Complex Role of Branched Chain Amino Acids in Diabetes and Cancer

@inproceedings{OConnell2013TheCR,
  title={The Complex Role of Branched Chain Amino Acids in Diabetes and Cancer},
  author={Thomas M. O’Connell},
  booktitle={Metabolites},
  year={2013}
}
The obesity and diabetes epidemics are continuing to spread across the globe. There is increasing evidence that diabetes leads to a significantly higher risk for certain types of cancer. Both diabetes and cancer are characterized by severe metabolic perturbations and the branched chain amino acids (BCAAs) appear to play a significant role in both of these diseases. These essential amino acids participate in a wide variety of metabolic pathways, but it is now recognized that they are also… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 79 REFERENCES

Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis.

  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2005
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Glutaminolysis activates Rag-mTORC1 signaling.

  • Molecular cell
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells.

  • Biochemical and biophysical research communications
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL