The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling

@article{Bockaert2021TheCF,
  title={The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling},
  author={Jo{\"e}l Bockaert and Julie Perroy and Fabrice Ango},
  journal={The Journal of Neuroscience},
  year={2021},
  volume={41},
  pages={5567 - 5578}
}
G-protein-coupled receptors can be constitutively activated following physical interaction with intracellular proteins. The first example described was the constitutive activation of Group I metabotropic glutamate receptors (mGluR: mGluR1,5) following their interaction with Homer1a, an activity-inducible early-termination variant of the scaffolding protein Homer that lacks dimerization capacity (Ango et al., 2001). Homer1a disrupts the links, maintained by the long form of Homer (cross-linking… 
Group I Metabotropic Glutamate Receptors and Interacting Partners: An Update
TLDR
The data from recent studies are analyzed and an update is provided on the biochemical and physiological properties of a set of proteins or molecules that interact with and thus regulate mGlu1/5 receptors.

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