The Competitive a-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate Receptor Antagonist LY 293558 Attenuates and Reverses Analgesic Tolerance to Morphine But Not to Delta or Kappa Opioids 1

@inproceedings{Kest1997TheCA,
  title={The Competitive a-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate Receptor Antagonist LY 293558 Attenuates and Reverses Analgesic Tolerance to Morphine But Not to Delta or Kappa Opioids 1},
  author={Benjamin Kest and Gabrielle L. McLemore and Bernard Kao and Charles E. Inturrisi},
  year={1997}
}
Antagonists of the NMDA type of excitatory amino acid (EAA) receptor attenuate or reverse the development of tolerance to the analgesic effects of the mu opioid agonist morphine, the delta-1 opioid agonist DPDPE but not the kappa-1 agonist U50,488H or the kappa-3 agonist naloxone benzoylhydrazone. The role of the AMPA subtype of EAA receptor in analgesic tolerance was examined using LY293558, a selective competitive antagonist that is active after systemic administration. Administration of… CONTINUE READING