The Comparative Amnestic Effects of Midazolam, Propofol, Thiopental, and Fentanyl at Equisedative Concentrations

@article{Veselis1997TheCA,
  title={The Comparative Amnestic Effects of Midazolam, Propofol, Thiopental, and Fentanyl at Equisedative Concentrations},
  author={R. Veselis and R. Reinsel and V. Feshchenko and M. Wroński},
  journal={Anesthesiology},
  year={1997},
  volume={87},
  pages={749–764}
}
  • R. Veselis, R. Reinsel, +1 author M. Wroński
  • Published 1997
  • Medicine
  • Anesthesiology
  • Background: The authors evaluated the effects of midazolam, propofol, thiopental, and fentanyl on volunteer participants' memory for words and pictures at equisedative concentrations. Methods: Sixty‐seven healthy volunteers were randomized to receive intravenous infusions of midazolam (n = 11), propofol (n = 11), thiopental (n = 10), fentanyl with ondansetron pretreatment (n = 11), ondansetron alone (n = 8), or placebo (n = 16) in a double‐blind design. Three increasing and then two decreasing… CONTINUE READING
    210 Citations
    Thiopental and propofol affect different regions of the brain at similar pharmacologic effects.
    • 81
    Drug-induced Amnesia Is a Separate Phenomenon from Sedation: Electrophysiologic Evidence
    • 73
    A triazolam/amphetamine dose–effect interaction study: dissociation of effects on memory versus arousal
    • 26
    Facilitation of Serotonergic Activity and Amnesia in Rats Caused by Intravenous Anesthetics
    • 36
    • PDF

    References

    SHOWING 1-10 OF 57 REFERENCES
    Midazolam in combination with propofol for sedation during local anesthesia.
    • 81