The Combined Inducible Nitric Oxide Synthase Inhibitor and Free Radical Scavenger Guanidinoethyldisulfide Prevents Multiple Low-Dose Streptozotocin-Induced Diabetes In Vivo and Interleukin-1&bgr;-Induced Suppression of Islet Insulin Secretion In Vitro

@article{Mabley2004TheCI,
  title={The Combined Inducible Nitric Oxide Synthase Inhibitor and Free Radical Scavenger Guanidinoethyldisulfide Prevents Multiple Low-Dose Streptozotocin-Induced Diabetes In Vivo and Interleukin-1\&bgr;-Induced Suppression of Islet Insulin Secretion In Vitro},
  author={J. Mabley and G. Southan and A. Salzman and C. Szab{\'o}},
  journal={Pancreas},
  year={2004},
  volume={28},
  pages={e39-e44}
}
Inhibition of inducible nitric oxide synthase has been shown to be antiinflammatory in a variety of disease states. Type I diabetes is an autoimmune disease resulting from the specific destruction of the insulin-producing pancreatic &bgr; cells. Here we demonstrate that guanidinoethyldisulfide (GED), a combined inducible nitric oxide synthase inhibitor and peroxynitrite/reactive oxygen species scavenger reduces the hyperglycemia and incidence of type I diabetes induced in mice by multiple low… Expand
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TLDR
By concomitantly enhancing insulin and paradoxically potentiating insulin sensitivity, this study unveils a novel, unique, and long-lasting antidiabetic characteristic of upregulating HO with hemin that could be exploited against insulin-resistant and insulin-dependent diabetes. Expand
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TLDR
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The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.
TLDR
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TLDR
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TLDR
This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults. Expand
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TLDR
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Differential Mechanisms of Nitric Oxide- and Peroxynitrite-Induced Cell Death
TLDR
It is suggested that NO is a potent toxin independent of peroxynitrite formation, which was supported by the other findings. Expand
MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity.
TLDR
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Nitric oxide and peroxynitrite in health and disease.
TLDR
Current evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion, which is presented in detail in this review. Expand
High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals--clinical potential in inflammatory disorders.
TLDR
It is suggested that Epidemiological associations of high urate levels with low risk for Parkinson's disease may reflect urate's radical scavenging activity, and suggest the possible utility of dietary purines in prevention or treatment of CNS inflammatory disorders. Expand
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TLDR
GED significantly inhibited nitric oxide and nitrotyrosine formation and decreased destruction of beta-cells in NOD mouse islets incubated in vitro with the combination of proinflammatory cytokines interleukin 1-beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and interferon-Gamma (IFN-gamma). Expand
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OBJECTIVE Nitric oxide (NO), generated by inducible nitric oxide synthase (iNOS), has been implicated in beta-cell destruction in type 1 diabetes. In the present study, we tested a highly selectiveExpand
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TLDR
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TLDR
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TLDR
It is shown that nitric oxide treatment for 30–90 min causes inhibition of insulin secretion, DNA damage and disturbs sub-cellular organization in rat and human islets of Langerhans and HIT-T15 cells and Cytokine-induced apoptosis was observed specifically in islet beta cells. Expand
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TLDR
S-methyl-L-thiocitrulline can potently block cytokine induced activation of nitric oxide synthase in pancreatic islets, but using the presently adopted administration protocol failed to protect against development of insulin-dependent diabetes mellitus in vivo. Expand
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