The Combined Effects of Amino Acid Substitutions and Indels on the Evolution of Structure within Protein Families

@inproceedings{Zhang2010TheCE,
  title={The Combined Effects of Amino Acid Substitutions and Indels on the Evolution of Structure within Protein Families},
  author={Zheng Zhang and Yuxiao Wang and Lushan Wang and Pei-ji Gao},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND In the process of protein evolution, sequence variations within protein families can cause changes in protein structures and functions. However, structures tend to be more conserved than sequences and functions. This leads to an intriguing question: what is the evolutionary mechanism by which sequence variations produce structural changes? To investigate this question, we focused on the most common types of sequence variations: amino acid substitutions and insertions/deletions… CONTINUE READING
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