The Combined Effect of Sleep Deprivation and Western Diet on Spatial Learning and Memory: Role of BDNF and Oxidative Stress

@article{Alzoubi2012TheCE,
  title={The Combined Effect of Sleep Deprivation and Western Diet on Spatial Learning and Memory: Role of BDNF and Oxidative Stress},
  author={Karem H Alzoubi and Omar F Khabour and Heba A. Salah and Baraa E. Abu Rashid},
  journal={Journal of Molecular Neuroscience},
  year={2012},
  volume={50},
  pages={124-133}
}
Either sleep deprivation or Western diet can impair learning and memory via induction of oxidative stress, which results in neuronal damage and interference with the neurotransmission. In this study, we examined the combined effect of sleep deprivation and Western diet on hippocampus-dependent spatial learning and memory. In addition, possible molecular targets for sleep deprivation and Western diet-induced cognitive impairments were investigated. Sleep deprivation was induced in rats using the… CONTINUE READING
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