The Combined Effect of Environmental and Host Factors on the Emergence of Viral RNA Recombinants

@inproceedings{Jaag2010TheCE,
  title={The Combined Effect of Environmental and Host Factors on the Emergence of Viral RNA Recombinants},
  author={Hannah Miriam Jaag and Peter D Nagy},
  booktitle={PLoS pathogens},
  year={2010}
}
Viruses are masters of evolution due to high frequency mutations and genetic recombination. In spite of the significance of viral RNA recombination that promotes the emergence of drug-resistant virus strains, the role of host and environmental factors in RNA recombination is poorly understood. Here we report that the host Met22p/Hal2p bisphosphate-3'-nucleotidase regulates the frequency of viral RNA recombination and the efficiency of viral replication. Based on Tomato bushy stunt virus (TBSV… CONTINUE READING

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