Paul Ehrlich and 606.
- MedicineArchives of neurology
Salvarsan was the organic arsenical that was the first agent to be used effectively throughout the world in the treatment of syphilis, and originated the field of chemotherapy.
The Dawn of Immunology: The Era of Paul Ehrlich
In an eventful period in which German medicine was just turning away from Romanticism and Natural Philosophy and when the scientific way of thinking and experimentation was making strong progress,…
The Immunological Self: A Centenary Perspective
- HistoryPerspectives in biology and medicine
The celebrated debate between the immunological cell advocates, led by Metchnikoff, and the German humor advocates, was in full sway at the meeting, giving historians an interesting case study of the decline of a descriptive, teleological, even vitalistic vision of biology being replaced by the physicochemical reductionist program.
Immunology's Coming of Age
- Biology, MedicineFront. Immunol.
This treatise describes the development of immunology as a scientific discipline with a focus on its foundation, and perspectives on immunology progressed from a dichotomy between cellular-unspecific innate immunity and humoral-specific acquired immunity, toward the concept of complementary binarity.
Immunocompetence and Malignancy
In June of 1908, Paul Ehrlich, the founder of immunology, lectured at the University of Amsterdam on the subject of cancer. His remarks included the following: “the understanding of natural immunity…
Hugh Ross's Curious Lymphocyte Experiments
- MedicinePerspectives in biology and medicine
Hugh Campbell Ross began his experiments on white blood cells and cancer by suspending peripheral blood cells in a solution of agar gel, and claimed to have observed rapid division in them, although at that time they were looked upon as end cells without a future.
Monoclonal antibodies in the prehybridoma era: a brief historical perspective and personal reminiscence.
- BiologyClinical lymphoma
Monoclonal antibodies have been shown to have efficacy in cancer therapy, particularly in patients with lymphoma and breast cancer, and it is likely that this approach, alone and in combination with other modalities, will prove useful for patients with additional types of malignancies.
The History of Gold Therapy for Tuberculosis
- MedicineJournal of the history of medicine and allied sciences
This is a historical study of the popularization of a medical therapy contrary to pertinent experimental findings, popularized by Danish physicians in the mid-1920s, despite consistently negative experimental results, based on Paul Ehrlich's theories of antimicrobial drug effects.
Immunopathology of Malignant Disease in Humans
Almost a half century after the suggestion that there was an immune response to neoplasms, Foley (1953) dem onstrated the presence of specific antigenicity in experimental tumors and Prehn and Main (1957) confirmed and extended Foley's observations.
Magic bullets and moving targets: antibiotic resistance and experimental chemotherapy, 1900-1940.
The paper reconstructs the concept that was put forward by the German immunologist Paul Ehrlich in 1907 of induced resistance as an induced and inheritable trait of microbial species, which became one of the more important laboratory models of twentieth-century immunological research.