The Collagen Chaperone HSP47 Is a New Interactor of APP that Affects the Levels of Extracellular Beta-Amyloid Peptides

  title={The Collagen Chaperone HSP47 Is a New Interactor of APP that Affects the Levels of Extracellular Beta-Amyloid Peptides},
  author={Federico T. Bianchi and P. Della Camera and Ugo Ala and Daniele Imperiale and Antonio Migheli and Enrica Boda and Filippo Tempia and Gaia E. Berto and Ylenia Bosio and Salvatore Oddo and Frank M LaFerla and Stefano Taraglio and Carlos G Dotti and Ferdinando Di Cunto},
  journal={PLoS ONE},
Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive decline of cognitive function that represents one of the most dramatic medical challenges for the aging population. Aβ peptides, generated by processing of the Amyloid Precursor Protein (APP), are thought to play a central role in the pathogenesis of AD. However, the network of physical and functional interactions that may affect their production and deposition is still poorly understood. The use of a… 

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