The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics

@article{Chesler2008TheCC,
  title={The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics},
  author={Elissa J. Chesler and Darla R Miller and Lisa R. Branstetter and Leslie Galloway and Barbara L. Jackson and Vivek M. Philip and Brynn H. Voy and Cymbeline T. Culiat and David W Threadgill and Robert W. Williams and Gary A. Churchill and Dabney K. Johnson and Kenneth F. Manly},
  journal={Mammalian Genome},
  year={2008},
  volume={19},
  pages={382-389}
}
Complex traits and disease comorbidity in humans and in model organisms are the result of naturally occurring polymorphisms that interact with each other and with the environment. To ensure the availability of resources needed to investigate biomolecular networks and systems-level phenotypes underlying complex traits, we have initiated breeding of a new genetic reference population of mice, the Collaborative Cross. This population has been designed to optimally support systems genetics analysis… CONTINUE READING
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