The Collaborative Cross as a Resource for Modeling Human Disease: CC011/Unc, a New Mouse Model for Spontaneous Colitis

@inproceedings{Rogala2013TheCC,
  title={The Collaborative Cross as a Resource for Modeling Human Disease: CC011/Unc, a New Mouse Model for Spontaneous Colitis},
  author={Allison R. Rogala and Andrew P Morgan and Alexis M. Christensen and Terry J. Gooch and Timothy A. H. Bell and Darla R Miller and Virginia L. Godfrey and Fernando Pardo-Manuel de Villena},
  booktitle={Mammalian Genome},
  year={2013}
}
Inflammatory bowel disease (IBD) is an immune-mediated condition driven by improper responses to intestinal microflora in the context of environmental and genetic background. GWAS in humans have identified many loci associated with IBD, but animal models are valuable for dissecting the underlying molecular mechanisms, characterizing environmental and genetic contributions and developing treatments. Mouse models rely on interventions such as chemical treatment or introduction of an infectious… CONTINUE READING

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