The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.

@article{Gool1997TheCS,
  title={The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.},
  author={Alain J van Gool and Elisabetta Citterio and Suzanne Rademakers and Roselinde van Os and W. Mary Vermeulen and Angelos Constantinou and Jean Marc Egly and Dirk Bootsma and Jan Hendrik Jozef Hoeijmakers},
  journal={The EMBO journal},
  year={1997},
  volume={16 19},
  pages={
          5955-65
        }
}
Transcription-coupled repair (TCR), a subpathway of nucleotide excision repair (NER) defective in Cockayne syndrome A and B (CSA and CSB), is responsible for the preferential removal of DNA lesions from the transcribed strand of active genes, permitting rapid resumption of blocked transcription. Here we demonstrate by microinjection of antibodies against CSB and CSA gene products into living primary fibroblasts, that both proteins are required for TCR and for recovery of RNA synthesis after UV… CONTINUE READING

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