The Cochlear CRF Signaling Systems and their Mechanisms of Action in Modulating Cochlear Sensitivity and Protection Against Trauma

@article{Graham2011TheCC,
  title={The Cochlear CRF Signaling Systems and their Mechanisms of Action in Modulating Cochlear Sensitivity and Protection Against Trauma},
  author={Christine E. Graham and Johnvesly Basappa and Şevin Turcan and Douglas E. Vetter},
  journal={Molecular Neurobiology},
  year={2011},
  volume={44},
  pages={383-406}
}
A key requirement for encoding the auditory environment is the ability to dynamically alter cochlear sensitivity. However, merely attaining a steady state of maximal sensitivity is not a viable solution since the sensory cells and ganglion cells of the cochlea are prone to damage following exposure to loud sound. Most often, such damage is via initial metabolic insult that can lead to cellular death. Thus, establishing the highest sensitivity must be balanced with protection against cellular… CONTINUE READING

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