The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

@article{Vega2000TheCP,
  title={The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor $\alpha$ in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes},
  author={R. Vega and J. Huss and D. Kelly},
  journal={Molecular and Cellular Biology},
  year={2000},
  volume={20},
  pages={1868 - 1876}
}
ABSTRACT Peroxisome proliferator-activated receptor α (PPARα) plays a key role in the transcriptional control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study we sought to determine whether the recently identified PPAR gamma coactivator 1 (PGC-1) is capable of coactivating PPARα in the transcriptional control of genes encoding FAO enzymes. Mammalian cell cotransfection experiments demonstrated that PGC-1 enhanced PPARα-mediated transcriptional activation of… Expand
Statins enhance peroxisome proliferator-activated receptor γ coactivator-1α activity to regulate energy metabolism
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
  • C. Qi, Y. Zhu, +7 authors J. Reddy
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)*
The Human Medium Chain Acyl-CoA Dehydrogenase Gene Promoter Consists of a Complex Arrangement of Nuclear Receptor Response Elements and Sp1 Binding Sites (*)
...
1
2
3
4
5
...