The Co-Operonic PE25/PPE41 Protein Complex of Mycobacterium tuberculosis Elicits Increased Humoral and Cell Mediated Immune Response

@article{Tundup2008TheCP,
  title={The Co-Operonic PE25/PPE41 Protein Complex of Mycobacterium tuberculosis Elicits Increased Humoral and Cell Mediated Immune Response},
  author={Smanla Tundup and Niteen Pathak and Madduri Ramanadham and Sangita Mukhopadhyay and Kolluri Janaki Rama Murthy and Nasreen Zafar Ehtesham and Seyed E. Hasnain},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={126 - 135}
}
BACKGROUND Many of the PE/PPE proteins are either surface localized or secreted outside and are thought to be a source of antigenic variation in the host. The exact role of these proteins are still elusive. We previously reported that the PPE41 protein induces high B cell response in TB patients. The PE/PPE genes are not randomly distributed in the genome but are organized as operons and the operon containing PE25 and PPE41 genes co-transcribe and their products interact with each other… CONTINUE READING

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