The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidase.

@article{Kosowska2002TheCR,
  title={The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidase.},
  author={Klaudia Kosowska and Jesper Reinholdt and Lone Kjar Rasmussen and Artur Sabat and Jan Potempa and Mogens Kilian and Knud Poulsen},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 14},
  pages={
          11987-94
        }
}
  • Klaudia Kosowska, Jesper Reinholdt, +4 authors Knud Poulsen
  • Published in
    The Journal of biological…
    2002
  • Biology, Medicine
  • Clostridium ramosum is part of the normal flora in the human intestine. Some strains produce an IgA proteinase that specifically cleaves human IgA1 and the IgA2m(1) allotype. This prolylendopeptidase was purified from a broth culture supernatant, and N-terminal sequences of the native protein and tryptic fragments thereof were determined. A fragment of the iga gene encoding the IgA proteinase was isolated using degenerate primers in PCR, and the complete gene was obtained by inverse PCR. The… CONTINUE READING

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